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Search Results for " gls1 inhibitor "

13

Compounds

Cat No. Product Name Synonyms Targets
T37222 GLS1 Inhibitor
GLS1 inhibitor is an inhibitor of glutaminase 1 (GLS1; IC50= 0.021 μM).1It inhibits the growth of NCI H1703 non-small cell lung cancer (NSCLC) cellsin vitro(GI50= 0.011 μM). GLS1 inhibitor (100 mg/kg) reduces tumor growt...
T64211 GLS1 Inhibitor-3
GLS1 Inhibitor-3 (compound C147) is a potent inhibitor of GLS1 (IC50: 27.98 nM) and exhibits anti-proliferative effects.
T72679 GLS1 Inhibitor-4 Glutaminase
GLS1 Inhibitor-4 (compound 41e) is a powerful GLS1 inhibitor, demonstrating an IC50 of 11.86 nM. It exhibits antiproliferative effects, substantial metabolic stability, and strong GLS1 binding affinity. Furthermore, it i...
T64259 GLS1 Inhibitor-5
GLS1 Inhibitor-5 (compound 24y) is a selective, orally active inhibitor of glutaminase 1 (GLS1) (IC50: 68 nM). gLS1 Inhibitor-5 induces apoptosis and exhibits anti-tumour effects.
T72708 GLS1 Inhibitor-6
GLS1 Inhibitor-6 inhibitor ( IC 50 =68 nM), shows 220-fold selectivity for GLS2. GLS1 Inhibitor-6 shows good anti-tumor activity, antitumor cell proliferation activity and induces apoptosis .
T79340 GLS1 Inhibitor-7 Glutaminase
GLS1 Inhibitor-7 (compound 4d) serves as a GLS1 antagonist with an IC50 value of 46.7 μM, demonstrating potential applications in anticancer, antiaging, and antiobesity therapies [1].
T6791 BPTES transporter , Glutaminase
BPTES(IC50 of 0.16 μM) is an effective and specific GlutamiN/Ase GLS1 (KGA) inhibitor.
T11412 IPN60090 GLS1-IN-1 Others , transporter
IPN60090 is a novel, potent, orally bioavailable, renal-type glutaminase (GLS1)-specific inhibitor with an IC50 value of 31 nM for GLS1. IPN60090 has potential anticancer and immunostimulant/immunomodulatory activity, se...
T37385 Glutaminase-IN-3 Glutaminase
Glutaminase-IN-3 is a potent Glutaminase 1 inhibitor with potential antitumor activity and inhibits GLS1 for cancer research.
T6797 Telaglenastat CB 839,CB839,CB-839 transporter , Glutaminase , Autophagy
Telaglenastat (CB 839) (IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, for recombinant human GAC.
T39309 Telaglenastat hydrochloride CB-839 hydrochloride
Telaglenastat (CB-839) hydrochloride is a first-in-class, reversible, and orally active inhibitor of glutaminase 1 (GLS1). It selectively inhibits the splice variants of GLS1, specifically KGA (kidney-type glutaminase) a...
T73458 LWG-301
LWG-301, an allosteric inhibitor of Glutaminase 1 (GLS1), demonstrates a potent inhibition with an IC50 value of 7 nM. It effectively impedes glutamine metabolism and elevates intracellular ROS levels, thereby inducing a...
T39544 IPN60090 dihydrochloride IPN60090 dihydrochloride
IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-6009...
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